Background: Prostate cancer is a disease that affects the male population, especially after the age of 45. There are several risk factors, some modifiable, on which prevention strategies must be designed to avoid even doubtful prostate antigen levels.

Objective: Determine the correlation of risk factors for prostate cancer with doubtful prostate antigen values.

Methods: During the year 2022, a quantitative correlational study was carried out in the population of four clinics belonging to the “East Area” of the Camagüey municipality. The universe consisted of 80 patients in whom prostate antigen determination was performed. The variables were: age groups, color of the skin, family history of prostate cancer, previous history of other prostate disease and behavioral risks. The corresponding statistical analysis was performed for this type of study.

Results: There was a predominance of patients with doubtful PSA/normal PSA in a ratio of 13/4 in the age group (˃45 years). There was no relationship between doubtful PSA values and skin color (OR 0.74). Statistically significant relationship was found between a family history of prostate cancer and previous history of prostate conditions with doubtful PSA values (OR 5.57 and 2.04, respectively). The strongest influence was found when correlating behavioral risks and doubtful PSA values.

Conclusions: Behavioral risks constitute modifiable factors on which health promotion and education actions can be designed to prevent the progression to high PSA levels and eventually prostate cancer. Active screening when the other associated factors are present is recommended.